Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin.
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چکیده
منابع مشابه
Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin.
The treatment of rats with cis-platinum for 7 days caused a profound, and seemingly selective, decrease (70-80%) in the microsomal cytochrome P-450 levels in the testis. This decrease was accompanied by marked reductions (70-80%) in steroid 17 alpha-hydroxylase activity and in plasma testosterone concentration. The treatment of rats with human chorionic gonadotropin partially restored the cytoc...
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The mechanisms responsible for gonadotropin-induced testicular desensitization were analyzed by direct assay of androgen biosynthetic enzymes and cytochrome P-450 in microsomes and cytosol from testes of adult male rats. Animals were treated with single subcutaneous doses of human chorionic gonadotropin (hCG) (2 and 10 pg) to induce a post-stimulation decrease in testosterone production, previo...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)88938-4